PXD048846-1

PXD048846 is an original dataset announced via ProteomeXchange.

Title	Identification of RNA Pol II polymerase interactome in ALL cells
Description	RNA polymerase II is a protein encoded by the POLR2A gene in humans. In coordination with a wide array of interacting partners, RNA polymerase II has been shown to participate in the regulation of the cell cycle, transcription, and splicing, all of which are important for ALL growth. Here, we investigated the RNA Pol II polymerase interactome, focusing on the splicing-related apparatus to identify the splicing factors involved in co-transcriptional splicing, which is important for ALL cell growth.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_12:35:06.689.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vishwajeeth Pagala
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-24 10:04:12	ID requested
⏵ 1	2025-05-06 12:35:07	announced

Jin Q, Harris E, Myers JA, Mehmood R, Cotton A, Shirnekhi HK, Baggett DW, Wen JQ, Schild AB, Bhansali RS, Klein J, Narina S, Pieters T, Yoshimi A, Pruett-Miller SM, Kriwacki R, Abdel-Wahab O, Malinge S, Ntziachristos P, Obeng EA, Crispino JD, Disruption of cotranscriptional splicing suggests RBM39 is a therapeutic target in acute lymphoblastic leukemia. Blood, 144(23):2417-2431(2024) [pubmed]

10.1182/blood.2024024281;

submitter keyword: RNA polymerase II

acute lymphoblastic leukemia

proteomics

proteome

Dr. John Crispino
contact affiliation	Member, St. Jude Faculty / Director, Division of Experimental Hematology / Wall Street Committee Endowed Chair St. Jude Children's Reserch Jospital Memphis, TN 38105
contact email	John.Crispino@STJUDE.ORG
lab head
Vishwajeeth Pagala
contact affiliation	St. Jude Children's Research Hospital
contact email	vishwajeeth.pagala@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD048846

PRIDE project URI

• PRIDE
  1. PXD048846
     1. Label: PRIDE project
     2. Name: Identification of RNA Pol II polymerase interactome in ALL cells