PXD048835 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profiling of clinical isolates and reference strain of H-34 Mycoplasma hominis to study phenotypic adaptation |
| Description | Mycoplasma hominis (M. hominis) belongs to the class Mollicutes, characterized by a very small genome size, metabolic pathway reduction, including transcription factors, and the absence of a cell wall. Despite this, they adapt well not only to specific niches within the host organism but can also spread throughout the body, colonizing various organs and tissues. The mechanisms of adaptation in M. hominis, as well as the pathways regulating them, are poorly understood. It is known that when adapting to adverse conditions, mycoplasmas can undergo phenotypic switches that may persist for several generations. To investigate the adaptive properties of M. hominis associated with survival in the host organism, we conducted a comparative proteogenomic analysis of 8 clinical isolates of M. hominis obtained from patients with urogenital infections, along with the laboratory strain H-34. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-06-22 |
| AnnouncementXML | Submission_2024-06-22_08:55:53.594.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD048835 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Kirill Sikamov |
| SpeciesList | scientific name: Metamycoplasma hominis; NCBI TaxID: 2098; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-01-24 05:11:51 | ID requested | |
| ⏵ 1 | 2024-06-22 08:55:54 | announced | |
| 2 | 2024-10-22 06:46:47 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.6019/PXD048835; |
| 10.3389/fcimb.2024.1398706; |
| Pobeguts OV, Galaymina MA, Sikamov KV, Urazaeva DR, Avshalumov AS, Mikhailycheva MV, Babenko VV, Smirnov IP, Gorbachev AY, through proteogenomic profiling of clinical isolates. Front Cell Infect Microbiol, 14():1398706(2024) [pubmed] |
Keyword List
| submitter keyword: laboratory strain H-34, clinical isolates,Mycoplasma hominis |
Contact List
| Alexey Gorbachev |
|---|
| contact affiliation | Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (Lopukhin FRCC PCM), Head of the Proteomic Analysis Laboratory |
| contact email | gorbachev.a@rcpcm.ru |
| lab head | |
| Kirill Sikamov |
|---|
| contact affiliation | Laboratory of Proteomic Analysis, FSBIS SRI PCM FMBA of Russia |
| contact email | sikamov2000@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD048835 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048835
- Label: PRIDE project
- Name: Proteomic profiling of clinical isolates and reference strain of H-34 Mycoplasma hominis to study phenotypic adaptation
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