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PXD048806-1
PXD048806 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Effect of type I and type II kinase inhibitors on the LRRK2 proximity proteome |
| Description | Type I and type II inhibitors have been demonstrated to stabilize LRRK2 either in an active or inactive kinase conformation. Furthermore, one type I inhibitors show a marked reduction in LRRK2 N-terminal phosphorylation on Serine 910 and 935. In this study, we generated comparative proximity proteomes upon treatment of HEK293 cells stably expressing miniTurbo(mT)-LRRK2 with either the LRRK2 specific type I inhibitor MLi-2 or the type inhibitor GZD-824 previously shown to inhibit LRRK2 at the used concentration. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-19 |
| AnnouncementXML | Submission_2026-05-19_07:18:42.467.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD048806 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Christian Johannes Gloeckner |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-01-23 08:07:24 | ID requested | |
| ⏵ 1 | 2026-05-19 07:18:43 | announced |
Publication List
| 10.1101/2024.09.30.613622; |
| 10.1038/S44319-026-00806-4; |
| 10.6019/PXD048806; |
| 10.1038/s44319-026-00806-4; |
Keyword List
| submitter keyword: None |
Contact List
| Christian Johannes Gloeckner | |
|---|---|
| contact affiliation | German Center for Neurodegenerative Diseases (DZNE) Otfried-Müller-Strasse 23 72076 Tübingen Germany |
| contact email | johannes.gloeckner@dzne.de |
| lab head | |
| Christian Johannes Gloeckner | |
| contact affiliation | DZNE |
| contact email | johannes.gloeckner@dzne.de |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD048806 |
| PRIDE project URI |
Repository Record List
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