PXD048717 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | the Urine proteomics of pulmonary tuberculosis |
| Description | In the present study, we aimed to identify biomarkers for diagnosis of pulmonary tuberculosis (PTB) using urinary metabolomic and proteomic analysis. Methods: 40 urine samples were collected from PTB, lung cancer (LCA), community-acquired pneumonia (CAP) patients and healthy controls (HC), respectively. Biomarker panels were selected based on random forest (RF) analysis. Results: A total of 3,868 proteins and 47,528 metabolic features detected using pairwise comparisons. Using AUC≥0.8000 as a cutoff value, we picked up five protein biomarkers for PTB diagnosis. The five-protein panel yielded an AUC of PTB/HC, PTB/CAP and PTB/LCA were 0.9840, 0.9680 and 0.9310, respectively. Additionally, five metabolism biomarkers were selected for differential diagnosis purpose. By employment of the five-metabolism panel, we could differentiate PTB/HC at an AUC of 0.9940, PTB/CAP of 0.8920, and PTB/LCA of 0.8570, respectively. When the five protein and five metabolism biomarkers were combined, yielded an AUC of PTB/HC, PTB/CAP and PTB/LCA were 1.0000, 0.9220 and 0.9500, respectively. Conclusion: Our data demonstrate that the combination of metabolomic and proteomic analyses can identify a novel urine biomarker panel to diagnose PTB with high sensitivity and specificity. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-05-06 |
| AnnouncementXML | Submission_2025-05-06_12:54:07.833.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | kaixin zhong |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-01-19 10:17:21 | ID requested | |
| ⏵ 1 | 2025-05-06 12:54:08 | announced | |
Publication List
| 10.1186/s12014-024-09514-4; |
| Yu J, Yuan J, Liu Z, Ye H, Lin M, Ma L, Liu R, Ding W, Li L, Ma T, Tang S, Pang Y, Combined urine proteomics and metabolomics analysis for the diagnosis of pulmonary tuberculosis. Clin Proteomics, 21(1):66(2024) [pubmed] |
Keyword List
| submitter keyword: Proteomics |
| Metabolomics |
| Tuberculosis |
| Biomarkers |
| Urine |
Contact List
| Yu Pang |
|---|
| contact affiliation | Beijing Chest Hospital |
| contact email | pangyupound@163.com |
| lab head | |
| kaixin zhong |
|---|
| contact affiliation | shanghai bioprofile technology company |
| contact email | zhongkaixin@bioprofile.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048717
- Label: PRIDE project
- Name: the Urine proteomics of pulmonary tuberculosis
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