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PXD048666-1

PXD048666 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex
Description	We utilized a large-scale proteomic profiling strategy to quantitatively measure ADP-riboxanation (and classical ADP-ribosylation) levels of host proteins upon introduction of bacterial effectors. Notably, we identified the eukaryotic translation initiation factor 3 (eIF3) complex as a novel target of the OspC family proteins. ADP-riboxanation of eIF3 resulted in inhibition of bulk protein synthesis and SG assembly in infected host cells, which promoted intracellular bacterial proliferation.
HostingRepository	iProX
AnnounceDate	2024-01-18
AnnouncementXML	Submission_2024-01-17_23:08:04.965.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xian Wei
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-17 23:07:45	ID requested
⏵ 1	2024-01-17 23:08:05	announced
2	2024-05-09 20:53:47	announced	2024-05-10: Update information.

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: ADP-riboxanation, stress granule

Contact List

Xiaoyun Liu
contact affiliation	Peking University Health Science Center
contact email	xiaoyun.liu@bjmu.edu.cn
lab head
Xian Wei
contact affiliation	Peking University Health Science Center
contact email	xianwei@pku.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI