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PXD048644-1

PXD048644 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMultidimensional proteomic landscape of intercellular signaling in pancreatic cancer
DescriptionWe developed a multidimensional proteomic strategy to profile the glycosylated secreted and plasma membrane (S-PM) proteome of 100 human pancreatic tissue samples to an unprecedented depth, define cell-type origins of these S-PM proteins through spatial proteomics, and identify potential paracrine crosstalk, especially crosstalk mediated through tyrosine phosphorylation. Temporal dynamics during pancreatic tumor progression were further explored in a genetically engineered PDAC mouse model. Besides, generic shedding of membrane proteins in cancer and stroma regions of PDAC tumors was explored and validated through PRM-based absolute quantification.
HostingRepositoryPRIDE
AnnounceDate2024-09-10
AnnouncementXMLSubmission_2024-09-10_01:40:59.564.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPeiwu Huang
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480; Q Exactive HF-X; Orbitrap Fusion; LTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-17 05:38:59ID requested
12024-09-10 01:41:00announced
22024-10-22 06:57:56announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, Spatial proteomics, Phosphoproteomics, Pancreatic cancer, shedding, PRM, Glycoproteomics, Mouse, DDA, LC-MS/MS
Contact List
Ruijun Tian
contact affiliationDepartment of Chemistry, Southern University of Science and Technology, Shenzhen, China
contact emailtianrj@sustech.edu.cn
lab head
Peiwu Huang
contact affiliationSouthern University of Science and Technology
contact email11652005@mail.sustech.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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