PXD048617 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The post-biotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cell |
Description | This research explores the antiproliferative effects of short-chain fatty acid (SCFA) salts (magnesium acetate, sodium propionate, and sodium butyrate) on AGS gastric adenocarcinoma cells. Sodium butyrate (NaB) exhibited the most significant inhibitory impact. The study investigated synergistic interactions between NaB and the drug dexamethasone (Dex) using a combination index model. Dex and NaB at a 2:8 ratio showed strong synergy, surpassing mono treatments in inhibitory activity. NaB induced pro-oxidative effects, countered by Dex in combination. Cell population analyses indicated a shift towards apoptosis with Dex, NaB, and their combination. Proteomic analysis revealed downregulation of the oncogene TNS4, suggesting a potential mechanism for antiproliferative effects. These findings suggest NaB as a potential adjuvant therapy with Dex, prompting further exploration of combination therapies and molecular mechanisms, emphasizing the potential application of these postbiotics in gastric cancer treatment. |
HostingRepository | PRIDE |
AnnounceDate | 2024-02-21 |
AnnouncementXML | Submission_2024-02-20_21:39:18.797.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD048617 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Muhammad Alsherbiny |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-01-16 16:47:33 | ID requested | |
⏵ 1 | 2024-02-20 21:39:19 | announced | |
Publication List
Keyword List
submitter keyword: Gastric cancer, proteomics,Postbiotics, sodium butyrate, dexamethasone, synergy |
Contact List
Deep Bhuyan |
contact affiliation | NICM HRI, Western Sydney University, NSW, Australia |
contact email | d.bhuyan@westernsydney.edu.au |
lab head | |
Muhammad Alsherbiny |
contact affiliation | University of New South Wales, Victor Chang Cardiac Research Institute, Western Sydney University, Cairo University |
contact email | muhammad.alsherbiny@pharma.cu.edu.eg |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048617
- Label: PRIDE project
- Name: The post-biotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cell