PXD048605 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative proteomic analysis of the hemolymph and salivary glands of Rhodnius prolixus and R. colombiensis reveals candidates associated with differential lytic activity against Trypanosoma cruzi Dm28c and T. cruzi Y |
| Description | Some factors can facilitate or prevent T. cruzi transmission, i.e. vector immunity. Our work has managed to detect a stronger immune response against T. cruzi II in R. prolixus saliva and haemolymph, compared to that of R. colombiensis. Proteins from both species’ saliva and haemolymph were analysed for studying factors which might have been involved in such response; most proteins were detected in both species’ haemolymph, thereby indicating common immune mechanisms. Three proteins having oxidative immune activity were only expressed in R. prolixus. Lipocalin diversity and abundance predominated in R. prolixus saliva; these proteins are involved in nitric oxide metabolism and their role in immunity could be key in host defence against T. cruzi. Recognising the components modulating parasite transmission in a vector helps in understanding how such factors act independently and how they would act synergistically against T. cruzi, thereby enabling us to establish tools regarding Chaga’s disease epidemiology, aimed at predicting T. cruzi distribution and creating transmission control mechanisms. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-03-14 |
| AnnouncementXML | Submission_2024-03-14_08:40:19.723.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hamilton Barbosa |
| SpeciesList | scientific name: Rhodnius prolixus (Triatomid bug); NCBI TaxID: 13249; scientific name: Rhodnius colombiensis; NCBI TaxID: 162360; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | 4700 Proteomics Analyzer |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-01-16 07:56:11 | ID requested | |
| ⏵ 1 | 2024-03-14 08:40:20 | announced | |
Publication List
Keyword List
| submitter keyword: nitrophorins, Rhodnius prolixus,Chagas disease, Trypanosoma cruzi, trypanolytic factors |
Contact List
| Hamilton Julian |
|---|
| contact affiliation | Laboratorio de Investigaciones en Parasitología Tropical Universidad del Tolima |
| contact email | hjbarbosav@ut.edu.co |
| lab head | |
| Hamilton Barbosa |
|---|
| contact affiliation | Laboratorio de Investigaciones en Parasitología Tropical de la Universidad del Tolima |
| contact email | hjbarbosav@ut.edu.co |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048605
- Label: PRIDE project
- Name: Comparative proteomic analysis of the hemolymph and salivary glands of Rhodnius prolixus and R. colombiensis reveals candidates associated with differential lytic activity against Trypanosoma cruzi Dm28c and T. cruzi Y
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