PXD048592-1

PXD048592 is an original dataset announced via ProteomeXchange.

Title	KDF1 interacting protein in the ameloblast cell line
Description	Keratinocyte differentiation factor 1 (KDF1) was recently identified as a rare candidate gene of human congenital tooth agenesis. Extensive studies using mouse models have revealed the role of KDF1 in the development of epithelium-derived organs. For example, a study reported that KDF1 mutant mice Kdf1GT/GT exhibited enhanced proliferation and restricted differentiation of epidermal keratinocytes. Furthermore, preliminary findings reported that Kdf1 was mainly expressed in the inner enamel epithelium, which is the pre-differentiated form of ameloblasts, a dental epithelial cell, during tooth development. Thus, we hypothesized that KDF1 plays a crucial role in the differentiation of ameloblast and conducted in vitro experiments to investigate the role of KDF1 in ameloblast differentiation. As the robust evidence to clarify the mechanism through which KDF1 regulates ameloblast differentiation, LS-MS was employed to identify the possible proteins that can interact with KDF1. Thus, the raw data of LS-MS of this project are deposited in iProX database for further investigations. This study is the first to reveal the KDF1-mediated protein interaction network in ameloblast differentiation, not only providing help to broaden the functional cognition of KDF1, but also contributing to enhance the understanding of the gene regulatory network of enamel development.
HostingRepository	iProX
AnnounceDate	2024-01-16
AnnouncementXML	Submission_2025-01-01_19:38:44.762.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hangbo Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-15 23:20:41	ID requested
⏵ 1	2025-01-01 19:38:45	announced

Dataset with its publication pending

submitter keyword: KDF1

Dong Han
contact affiliation	Peking University School and Hospital of Stomatology
contact email	donghan@bjmu.edu.cn
lab head
Hangbo Liu
contact affiliation	Peking University School and Hospital of Stomatology
contact email	liuhangbo@bjmu.edu.cn
dataset submitter

iProX dataset URI