PXD048584-2

PXD048584 is an original dataset announced via ProteomeXchange.

Title	Protective Effects of Pt-N-C Nanozymes against Myocardial Ischemia-reperfusion Injury
Description	Effective therapeutic strategies for myocardial ischemia/reperfusion (I/R) injury are still lacking. Targeting reactive oxygen species (ROS), the major cause of I/R injury, provides a practical approach to alleviate myocardial damage after reperfusion procedure. Herein, we synthesized an innovative antioxidant nanozyme equipped with single-platinum-atom (PtsaN-C) for protecting against I/R injury. PtsaN-C exhibited potent multiple enzyme-mimicking activities with high-efficiency ROS-scavenging. Mechanistic studies demonstrated that excellent ROS-elimination performance in single platinum atom center was prior to that of platinum cluster center attributing to good synergistic effect and metallic electronic property with nitrogen-doping coordination structure. Systematic in vitro and in vivo studies confirmed that PtsaN-C counteracted ROS efficiently to restore cellular homeostasis and prevented apoptotic progress after I/R injury. PtsaN-C presented excellent biocompatibility and biosafety, making it promising for future clinical application. Current study broadens the horizon of single-atom nanomedicine against ROS-induced damage, offering a promising therapeutic avenue for treatment of I/R injury.
HostingRepository	iProX
AnnounceDate	2024-01-16
AnnouncementXML	Submission_2024-03-06_00:05:49.210.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tianbao Ye
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X; Thermo Fisher Scientific instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-15 21:05:29	ID requested
1	2024-01-15 21:05:41	announced
⏵ 2	2024-03-06 00:05:50	announced	2024-03-06: Update information.

Ye T, Chen C, Wang D, Huang C, Yan Z, Chen Y, Jin X, Wang X, Ding X, Shen C, Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury. Nat Commun, 15(1):1682(2024) [pubmed]

submitter keyword: single-atom nanozymes, ischemia/reperfusion injury, reactive oxygen species, apoptosis

Chengxing Shen
contact affiliation	Department of Cardiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
contact email	shencx@sjtu.edu.cn
lab head
Tianbao Ye
contact affiliation	Department of Cardiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
contact email	yetb0220@163.com
dataset submitter

iProX dataset URI