PXD048511-1

PXD048511 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of serum small extracellular vesicles identifies diagnostic biomarkers for neuroblastoma
Description	The search for new biomarkers for neuroblastoma diagnosis is driven by the need for improved accuracy, early detection, and personalized treatment of this particular type of cancer. Neuroblastoma is a pediatric cancer that primarily affects young children, and its diagnosis can be challenging due to its diverse clinical presentation and variable outcomes. Small extracellular vesicles (sEVs) have gained attention as potential tumor biomarkers due to their unique characteristics and their ability to reflect the molecular profile of the parent tumor cells. sEVs released by tumor cells can carry a cargo of proteins, nucleic acids (such as DNA and RNA), and other molecules that reflect the molecular diversity of the tumor. By analyzing the content of sEVs, researchers can gain insights into the heterogeneity of the tumor and potentially identify specific biomarkers associated with tumor subtypes or disease progression. sEVs can be found in various body fluids, this accessibility makes sEVs a promising source for non-invasive or minimally invasive diagnostic and monitoring approaches. sEVs are protected by a lipid bilayer membrane, which shields their cargo from degradation by enzymes and other harsh conditions in the extracellular environment. This stability allows sEVs to circulate in body fluids for extended periods, making them suitable for biomarker analysis. Here, we performed mass spectrometry-based proteomic analysis of serum sEVs to identify and validate potential protein biomarkers for diagnosis of NB.
HostingRepository	PRIDE
AnnounceDate	2024-01-13
AnnouncementXML	Submission_2024-01-12_17:24:48.955.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dongrui Ji
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-12 08:54:11	ID requested
⏵ 1	2024-01-12 17:24:49	announced
2	2024-10-22 06:21:54	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: extracellular vesicles, liquid biopsy,neuroblastoma, proteomic, biomarker

Lin Yang
contact affiliation	Department of Clinical Laboratory, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
contact email	lynyang73@163.com
lab head
Dongrui Ji
contact affiliation	Wayen Biotechnologies
contact email	878137865@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD048511
     1. Label: PRIDE project
     2. Name: Proteomic analysis of serum small extracellular vesicles identifies diagnostic biomarkers for neuroblastoma