PXD048492-1

PXD048492 is an original dataset announced via ProteomeXchange.

Title	Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma
Description	Even in the BCMA CAR-T era, multiple myeloma (MM) patients with high-risk genotypes have the poorest outcomes. We thus leveraged MMRF CoMMpass data to identify potential novel surface immunotherapeutic targets in high-risk MM. As described below, we focused on CD70, an immunotherapeutic target known to be upregulated on many hematologic and solid tumors but minimally expressed on normal tissue. While CD70 was previously explored in MM (McEarchern et al, Clin Cancer Res (2008)), it was not further investigated due to heterogeneous expression in newly diagnosed samples. Here we revisit this target to suggest cellular therapies against CD70 could be highly beneficial in high-risk MM patients, currently the greatest unmet need in the field.
HostingRepository	PRIDE
AnnounceDate	2025-11-28
AnnouncementXML	Submission_2025-11-28_13:28:53.061.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Arun Wiita
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-11 23:08:51	ID requested
⏵ 1	2025-11-28 13:28:54	announced

10.1182/blood.2024025536;

Kasap C, Izgutdina A, Pati, ñ, o-Escobar B, Kang AS, Chilakapati N, Akagi N, Manoj A, Johnson H, Rashid T, Werner J, Barpanda A, Geng H, Lin YT, Rampersaud S, Gil-Al, ó, s D, Sobh A, Dup, é, r, é, -Richer D, Aleman A, Wicaksono G, Kelii KMK, Dalal R, Ramos E, Vijayanarayanan A, Lakhani K, Salangsang F, Phojanakong P, Camara Serrano JA, Zakraoui O, Tariq I, Chari A, Chung A, Kumar AD, Martin TG, Wolf J, Wong SW, Steri V, Shanmugam M, Boise LH, Kortemme T, Parekh S, Stieglitz E, Licht JD, Karlon WJ, Barwick BG, Wiita AP, Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR T cells. Blood, 146(7):819-833(2025) [pubmed]

submitter keyword: CAR-T,CD 70, Multiple Myeloma, Immunotherapy

Arun Wiita
contact affiliation	Department of Laboratory Medicine Department of Bioengineering and Therapeutic Sciences University of California, San Francisco
contact email	arun.wiita@ucsf.edu
lab head
Arun Wiita
contact affiliation	U. of California, San Francisco
contact email	arun.wiita@ucsf.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD048492

PRIDE project URI

• PRIDE
  1. PXD048492
     1. Label: PRIDE project
     2. Name: Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma