PXD048492 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma |
| Description | Even in the BCMA CAR-T era, multiple myeloma (MM) patients with high-risk genotypes have the poorest outcomes. We thus leveraged MMRF CoMMpass data to identify potential novel surface immunotherapeutic targets in high-risk MM. As described below, we focused on CD70, an immunotherapeutic target known to be upregulated on many hematologic and solid tumors but minimally expressed on normal tissue. While CD70 was previously explored in MM (McEarchern et al, Clin Cancer Res (2008)), it was not further investigated due to heterogeneous expression in newly diagnosed samples. Here we revisit this target to suggest cellular therapies against CD70 could be highly beneficial in high-risk MM patients, currently the greatest unmet need in the field. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-28 |
| AnnouncementXML | Submission_2025-11-28_13:28:53.061.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Arun Wiita |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF Pro; Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-01-11 23:08:51 | ID requested | |
| ⏵ 1 | 2025-11-28 13:28:54 | announced | |
Publication List
Keyword List
| submitter keyword: CAR-T,CD 70, Multiple Myeloma, Immunotherapy |
Contact List
| Arun Wiita |
|---|
| contact affiliation | Department of Laboratory Medicine Department of Bioengineering and Therapeutic Sciences University of California, San Francisco |
| contact email | arun.wiita@ucsf.edu |
| lab head | |
| Arun Wiita |
|---|
| contact affiliation | U. of California, San Francisco |
| contact email | arun.wiita@ucsf.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD048492 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048492
- Label: PRIDE project
- Name: Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma
