PXD048456-1

PXD048456 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human PSP synaptoneurosome proteomics
Description	Investigation into PSP using proteomic techniques. Through the use of different human brain preps, the differences between those with Progressive supranuclear palsy and those without will be compared
HostingRepository	PRIDE
AnnounceDate	2025-08-25
AnnouncementXML	Submission_2025-08-24_21:53:27.989.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bethany Geary
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-11 05:00:53	ID requested
⏵ 1	2025-08-24 21:53:28	announced

Publication List

10.1038/s41593-025-01992-5;
McGeachan RI, Keavey L, Simzer EM, Chang YY, Rose JL, Spires-Jones MP, Gilmore M, Holt K, Meftah S, Ravingerova N, Scutariu C, Taylor LW, King D, Tzioras M, Tulloch J, Booker SA, Liaquat I, Hindley-Pollock N, Geary B, Smith C, Brennan PM, Durrant CS, Spires-Jones TL, Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy. Nat Neurosci, 28(8):1622-1634(2025) [pubmed]

10.1038/s41593-025-01992-5;

McGeachan RI, Keavey L, Simzer EM, Chang YY, Rose JL, Spires-Jones MP, Gilmore M, Holt K, Meftah S, Ravingerova N, Scutariu C, Taylor LW, King D, Tzioras M, Tulloch J, Booker SA, Liaquat I, Hindley-Pollock N, Geary B, Smith C, Brennan PM, Durrant CS, Spires-Jones TL, Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy. Nat Neurosci, 28(8):1622-1634(2025) [pubmed]

Keyword List

submitter keyword: Human, PSP, Brain, Synaptoneurosome

submitter keyword: Human, PSP, Brain, Synaptoneurosome

Contact List

Robert McGeachan
contact affiliation	UK DRI, University of Edinburgh
contact email	rmcgeach@exseed.ed.ac.uk
lab head
Bethany Geary
contact affiliation	University of Dundee
contact email	bgeary001@dundee.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD048456
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD048456

PRIDE project URI

Repository Record List

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