PXD048429-1
PXD048429 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Small Extracellular Vesicle-Mediated Intercellular Transformation of CXCR1-Low to CXCR1-High Tumor Cells Promotes the Progression of Head and Neck Squamous Cell Carcinoma |
| Description | The heterogeneity of tumor cells enables cancers to dynamically adapt to microenvironmental stresses during progression. However, the mechanism underlying the transformation and intercellular communication between heterogeneous tumor cells has remained elusive. Here, we report a “contagion model” that mediates intercellular transformation between heterogeneous tumor cells which facilitates tumor progression. Initially identifying heterogeneous expression of CXCR1, a receptor for interleukin-8, in head and neck squamous cell carcinoma (HNSCC) tumor cells, we found that CXCR1-High cells transformed CXCR1-Low cells into CXCR1-High cells through the secretion of small extracellular vesicles.We demonstrate that sEVs derived from interleukin-8-activated CXCR1-High cells contain high levels of ATP citrate lyase (ACLY) mediated this process. |
| HostingRepository | iProX |
| AnnounceDate | 2024-01-05 |
| AnnouncementXML | Submission_2024-09-01_23:02:45.264.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qiaoshi Xu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-01-10 19:11:31 | ID requested | |
| ⏵ 1 | 2024-09-01 23:02:45 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Small Extracellular Vesicle,CXCR1, Head and Neck Squamous Cell Carcinoma |
Contact List
| Zhien Feng | |
|---|---|
| contact affiliation | Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University |
| contact email | jyfzhen@126.com |
| lab head | |
| Qiaoshi Xu | |
| contact affiliation | Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University |
| contact email | xqsgarfield@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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