PXD048363 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Targeting HDAC6 to treat heart failure with preserved ejection fraction, Mouse heart LC-MS with PTMscan |
Description | Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research that demonstrates the efficacy of histone deacetylase 6 (HDAC6) inhibition in a genetic cardiomyopathy model, we investigate HDAC6’s role in HFpEF due to their shared mechanisms of inflammation and metabolism. Here, we show that inhibiting HDAC6 with TYA-018 effectively reverses established heart failure and its associated symptoms in HFpEF mouse models. Additionally, in mice lacking the Hdac6 gene, HFpEF progression is delayed and they are resistant to TYA-018’s effects. The efficacy of TYA-018 is comparable to a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and their combination shows enhanced effects. Mechanistically, TYA-018 restores gene expression related to hypertrophy, fibrosis, and mitochondrial energy production in HFpEF heart tissues. Furthermore, TYA-018 also inhibits activation of human cardiac fibroblasts and enhances mitochondrial respiratory capacity in cardiomyocytes. In this work, our findings show that HDAC6 impacts heart pathophysiology and is a promising target for HFpEF treatment. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-17 |
AnnouncementXML | Submission_2024-01-17_13:10:05.414.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Farshad Farshidfar |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-01-09 13:48:46 | ID requested | |
⏵ 1 | 2024-01-17 13:10:05 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Mouse, PTMscan, LC-MS, Heart, acetylated residue |
Contact List
Farshad Farshidfar |
contact affiliation | CVG group, Tenaya Therapeutics Inc., South San Francisco, CA United States |
contact email | ffarshidfar@tenayathera.com |
lab head | |
Farshad Farshidfar |
contact affiliation | Tenaya Therapeutics |
contact email | farshidfar@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048363
- Label: PRIDE project
- Name: Targeting HDAC6 to treat heart failure with preserved ejection fraction, Mouse heart LC-MS with PTMscan