PXD048272 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mapping in silico genetic networks of tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities |
Description | Cancers harbouring loss-of-function (LOF) alterations in tumour suppressor genes lack targeted therapies, thus alternative means to characterise gene function and identify vulnerabilities in these cancer cells are required. Here, we map the in silico genetic networks of KMT2D, a frequently mutated tumour suppressor gene, to demonstrate its utility in uncovering novel functional associations and vulnerabilities in cancer cells with tumour suppressor gene LOF alterations. In silico KMT2D networks revealed associated with histone modification, DNA replication, metabolism, and immune response. We identified synthetic lethal (SL) candidates encoding exising therapeutic targets. Analysing patient data from The Cancer Genome Atlas (TCGA) and the Personalized OncoGenomics Project (NCT021556210), we showed dysregulated pathways associated with SL candidates and elevated immune checkpoint response markers in KMT2DLOF cases, bringing forth evidence supporting KMT2D as a biomarker for immune checkpoint inhibitors. Our study presents a framework for identifying targetable vulnerabilities in cancers with tumour suppressor gene alterations. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-18 |
AnnouncementXML | Submission_2024-10-18_04:58:50.371.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Christopher Hughes |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | 6x(13)C labeled residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-01-05 03:27:18 | ID requested | |
⏵ 1 | 2024-10-18 04:58:50 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: metabolism,KMT2D, immune checkpoint inhibitor, genetic networks, synthetic lethality |
Contact List
Christopher Hughes |
contact affiliation | Manager Biological Mass Spectrometry Core Dalhousie University |
contact email | christopher.hughes@dal.ca |
lab head | |
Christopher Hughes |
contact affiliation | Dalhousie University |
contact email | christopher.hughes@dal.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD048272 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048272
- Label: PRIDE project
- Name: Mapping in silico genetic networks of tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities