PXD048264-1

PXD048264 is an original dataset announced via ProteomeXchange.

Title	Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in giant centipedes
Description	Venoms are biochemical arsenals that have emerged in numerous animal lineages, where they have coevolved with morphological and behavioural traits for venom production and delivery. In centipedes, venom evolution is thought to be constrained by the morphological complexity of their venom glands due to physiological limitations on the number of toxins produced by their secretory cells. Here, we show that the uneven toxin expression that results from these limitations have enabled giant centipedes to regulate the composition of their secreted venom despite having morphologically undifferentiated venom glands. We show that this control is likely achieved by the complex neuronal networks that innervate each venom gland subunit and is facilitated by morphological adaptations that circumvent the physiological evolutionary constraints on venom production. Our results suggest behavioural control over venom composition may be an overlooked aspect of venom biology and provide an example of how exaptation can facilitate evolutionary innovation and novelty.
HostingRepository	PRIDE
AnnounceDate	2024-08-29
AnnouncementXML	Submission_2024-08-28_16:22:29.457.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vanessa Schendel
SpeciesList	scientific name: Scolopendra morsitans; NCBI TaxID: 943129;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-04 20:13:53	ID requested
⏵ 1	2024-08-28 16:22:29	announced

Dataset with its publication pending

submitter keyword: centipede,venom modulation, mass spectrometry imaging, defence, venom gland, predation

Eivind A.
contact affiliation	Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, PO Box 1066 Blindern, 0316 Oslo, Norway
contact email	e.a.b.undheim@ibv.uio.no
lab head
Vanessa Schendel
contact affiliation	University of Queensland
contact email	v.schendel@uq.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD048264

PRIDE project URI

• PRIDE
  1. PXD048264
     1. Label: PRIDE project
     2. Name: Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in giant centipedes