PXD048243-1
PXD048243 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1 |
| Description | Collectively we have profiled a spectrum of sugar metabolite-interaction proteins, and discovered a unique signaling effect of FBP that supports Warburg effect in cancer cells via a histidine phosphorylation of PGAM1, which inspires the development of therapeutic tools of interrupting cancer cell metabolism. |
| HostingRepository | iProX |
| AnnounceDate | 2024-01-04 |
| AnnouncementXML | Submission_2024-06-30_20:07:58.795.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yanling Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | dimethylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-01-03 23:12:42 | ID requested | |
| ⏵ 1 | 2024-06-30 20:07:59 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: fructose-1,6-bisphosphate, cancer, pgam1, phosphohistidine (pHis), orthostatic, inhibitor |
Contact List
| Yiqun Geng | |
|---|---|
| contact affiliation | Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | gengyiqun@imm.ac.cn |
| lab head | |
| Yanling Zhang | |
| contact affiliation | Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | yanlingzhang@pku.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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