PXD048234-1
PXD048234 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | O-GlcNAcylation of E3 ubiquitin ligase SKP2 promotes hepatocellular carcinoma proliferation |
| Description | In this study, we found that SKP2 interacted with O-GlcNAc transferase (OGT) and was highly O-GlcNAcylated in hepatocellular carcinoma (HCC). Mechanistically, the O-GlcNAcylation at Ser34 stabilized SKP2 by reducing its ubiquitination and degradation mediated by APC-CDH1. Moreover, the O-GlcNAcylation of SKP2 enhanced its binding ability with SKP1, thereby enhancing its ubiquitin ligase function. Consequently, SKP2 facilitated the transition from the G1-S phase of the cell cycle by promoting the ubiquitin degradation of cell cycle-dependent kinase inhibitors p27 and p21. Additionally, targeting the O-GlcNAcylation of SKP2 significantly suppressed the proliferation of HCC. |
| HostingRepository | iProX |
| AnnounceDate | 2024-01-04 |
| AnnouncementXML | Submission_2024-01-03_18:56:20.955.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhirong Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-01-03 18:55:59 | ID requested | |
| ⏵ 1 | 2024-01-03 18:56:21 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: HCC, O-GlcNAcylation, SKP2, ubiquitination |
Contact List
| Luyi Huang | |
|---|---|
| contact affiliation | Key Laboratory of Molecular Biology for Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University |
| contact email | heligent@cqmu.edu.cn |
| lab head | |
| Zhirong Zhang | |
| contact affiliation | Key Laboratory of Molecular Biology for Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University |
| contact email | zzhir0206@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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