PXD048230 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | OGDH interactome upon glucose starvation |
| Description | The adaptation of tumor cells to metabolic stress is crucial for tumor development. We demonstrate that the translation of NRF2, a master regulator of antioxidant response, is controlled by the OGDH-METTL3 axis in melanoma for glucose starvation adaptation. To elucidate the regulatory mechanism of the OGDH-METTL3 axis during glucose starvation, we conducted co-immunoprecipitation and mass spectrometry analysis to identify the binding partner of OGDH that governs both the OGDH-METTL3 axis and tumor cell adaptation to glucose deprivation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-30 |
| AnnouncementXML | Submission_2026-06-30_03:34:30.743.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kejun Xu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-01-03 15:36:44 | ID requested | |
| ⏵ 1 | 2026-06-30 03:34:31 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: glucose starvation, Heat Shock Protein Family A Member 9 (HSPA9), α-ketoglutarate dehydrogenase (OGDH) |
Contact List
| Hang-zi Chen |
|---|
| contact affiliation | State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian Province, P. R. China |
| contact email | chenhz@xmu.edu.cn |
| lab head | |
| Kejun Xu |
|---|
| contact affiliation | Xiamen University |
| contact email | 1329490903@qq.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD048230 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048230
- Label: PRIDE project
- Name: OGDH interactome upon glucose starvation
