PXD048154-1

PXD048154 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Infrapatellar Fat Pad in Osteoarthritis
Description	The infrapatellar fat pad (IFP) is involved in the occurrence and progression of osteoarthritis (OA), yet the proteomic changes in the IFP during OA are not well understood. In this study, we selected the IFP from patients undergoing late-stage total knee arthroplasty as the experimental group, while the IFP from patients undergoing repair surgery for acute anterior cruciate ligament rupture served as the control group. Using label-free protein quantification technology, we analyzed the protein expression levels in the experimental and control groups. We identified 315 differentially expressed proteins that are primarily associated with functions such as coagulation, complement, fatty acid metabolism, and adipogenesis. These findings shed light on the potential molecular mechanisms underlying the involvement of the IFP in OA pathogenesis.
HostingRepository	iProX
AnnounceDate	2024-01-24
AnnouncementXML	Submission_2024-01-30_18:34:20.403.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bizhi Tu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-27 19:22:07	ID requested
⏵ 1	2024-01-30 18:34:20	announced

Dataset with its publication pending

submitter keyword: Osteoarthritis, infrapatellar fat pad, proteomic

Rende Ning
contact affiliation	The Third Affiliated Hospital of Anhui Medical University
contact email	nrd1972@outlook.com
lab head
Bizhi Tu
contact affiliation	The Third Affiliated Hospital of Anhui Medical University
contact email	1301535636@qq.com
dataset submitter

iProX dataset URI