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PXD048106-1

PXD048106 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	CD9-dependent extracellular vesicles mediate the propagation of ferroptosis
Description	Cells generate mass amount of EVs during ferroptosis. To evaluate the unique proteins secreted by ferroptitic EVs, and the potential mechnism of ferroptosis propagation through EV transportation,we analysed the proteomics of EVs from U-2 OS cells. U-2 OS cells were treated with DMSO or RSL3 (to induce ferroptosis) and EVs were collected from the culture medium.We further evaluated teh mice kidney derived EV proteomics and identified upregulated proteins in RSL3-treated mice. To elucidate the function of CD9-positive EVs, we generated wild type and CD9-KO HT1080 xenografts and treated the mice with RSL3 and enriched the xenograft EVs and performed proteomics analysis.
HostingRepository	iProX
AnnounceDate	2023-12-24
AnnouncementXML	Submission_2023-12-24_20:03:59.216.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tianyu Guo
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-24 20:03:28	ID requested
⏵ 1	2023-12-24 20:03:59	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: ferroptosis, extracellular vesicles

Contact List

Hai Huang
contact affiliation	Zhejiang University
contact email	haihuang@zju.edu.cn
lab head
Tianyu Guo
contact affiliation	Zhejiang University
contact email	0620197@zju.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI