PXD048089-1

PXD048089 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of paclitaxel-tolerant ovarian cancer OVCAR8-Persister cells revealed a metabolic shift to fatty acid oxidation
Description	Human ovarian adenocarcinoma OVCAR8 cells and paclitaxel-induced OVCAR8 -Persister cells (3 biological replicates) were collected in lysis buffer and then sonicated three times on ice. The supernatant represented the whole-cell extract. 4D-data independent acquisition (DIA)-based label-free quantitative proteomics was performed on a timsTOF Pro2 (Bruker Daltonics, USA) mass spectrometer coupled to a nanoElute UHPLC system (Bruker Daltonics, USA).
HostingRepository	PRIDE
AnnounceDate	2026-01-12
AnnouncementXML	Submission_2026-01-11_16:17:32.005.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hui Lin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-22 11:33:43	ID requested
⏵ 1	2026-01-11 16:17:33	announced

Lin H, Wang L, Chen H, Shen Y, Wang C, Xue Y, Zheng Z, Zhang Y, Xia D, Wu Y, Wang F, Li X, Cheng X, Wang H, Xu J, Lu W, Mitochondrial fatty acid oxidation as the target for blocking therapy-resistance and inhibiting tumor recurrence: The proof-of-principle model demonstrated for ovarian cancer cells. J Adv Res, 79():571-585(2026) [pubmed]

10.1016/j.jare.2025.03.026;

submitter keyword: ovarian cancer,persister cell, fatty acid oxidation, paclitaxel

Weiguo Lu
contact affiliation	Women’s Reproductive Health Laboratory of Zhejiang Province, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China
contact email	lbwg@zju.edu.cn
lab head
Hui Lin
contact affiliation	Women’s Reproductive Health Laboratory of Zhejiang Province, Women’s Hospital, Zhejiang University School of Medicine
contact email	3140102183@zju.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD048089

PRIDE project URI

• PRIDE
  1. PXD048089
     1. Label: PRIDE project
     2. Name: Proteomic analysis of paclitaxel-tolerant ovarian cancer OVCAR8-Persister cells revealed a metabolic shift to fatty acid oxidation