PXD048074 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Surface Proteome of Extracellular Vesicles and Correlation Analysis for Identification of Breast Cancer Biomarkers |
Description | Breast cancer (BC) is the second leading cause of death in Canadian women. Despite this, non-invasive early detection methods for BC have yet to be developed. Cells release various types of extracellular vesicles (EVs) as intercellular signals into biofluids, such as blood, reflecting the physiological state of the origin cell. It is by transmitting bioactive molecules between cells that EVs may regulate multiple pathologies in human diseases, including cancer. The detection of protein biomarkers present on the surface of EVs in depleted or enriched biofluids could enable the early diagnosis of BC. Therefore, we used two different approaches to study the surfactome of EVs from cancerous and non-cancerous cells. We found several potential biomarkers that may be involved in the early diagnosis of BC. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-21 |
AnnouncementXML | Submission_2024-05-21_10:21:29.174.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nico Hüttmann |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | biotinylated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-12-22 01:36:50 | ID requested | |
⏵ 1 | 2024-05-21 10:21:30 | announced | |
Publication List
H, ü, ttmann N, Li Y, Poolsup S, Zaripov E, D'Mello R, Susevski V, Minic Z, Berezovski MV, Surface Proteome of Extracellular Vesicles and Correlation Analysis Reveal Breast Cancer Biomarkers. Cancers (Basel), 16(3):(2024) [pubmed] |
10.3390/cancers16030520; |
Keyword List
submitter keyword: Surface proteins,Breast cancer, Proteomics, Biomarkers, Extracellular vesicles |
Contact List
Maxim Valentinovich Berezovski |
contact affiliation | Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada |
contact email | Maxim.Berezovski@uOttawa.ca |
lab head | |
Nico Hüttmann |
contact affiliation | John L. Holmes Mass Spectrometry Facility, Faculty of Science, University of Ottawa, Canada |
contact email | nhutt069@uottawa.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD048074 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048074
- Label: PRIDE project
- Name: Surface Proteome of Extracellular Vesicles and Correlation Analysis for Identification of Breast Cancer Biomarkers