PXD048067-1

PXD048067 is an original dataset announced via ProteomeXchange.

Title	Mevalonate pathway inhibition affects bladder cancer metastasis
Description	Metastasis is an important factor affecting the prognosis and survival of bladder cancer (BLCA) patients. Our previous study found that the mevalonate pathway is associated with the migratory ability of bladder cancer cells, but the exact mechanism is unclear. Here, we found that BLCA patients with mevalonate pathway activation had a poorer prognosis. Inhibition of the mevalonate pathway (simvastatin or zoledronic acid) resulted in a significant decrease in the migratory ability of BLCA cells. Therefore, we used proteomics to detect simvastatin- or zoledronic acid-treated BLCA cells to explore the effect of the mevalonate pathway on key proteins in BLCA cells.
HostingRepository	iProX
AnnounceDate	2024-09-09
AnnouncementXML	Submission_2024-09-08_19:58:06.966.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gang Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-21 18:54:48	ID requested
⏵ 1	2024-09-08 19:58:07	announced

Dataset with its publication pending

submitter keyword: Mevalonate pathway，Bladder cancer，Simvastatin，Zoledronic acid, RhoB

Yu Xiao
contact affiliation	Zhongnan Hospital of Wuhan University
contact email	yu.xiao@whu.edu.cn
lab head
Gang Wang
contact affiliation	Zhongnan Hospital of Wuhan University
contact email	gangwang.uro@whu.edu.cn
dataset submitter

iProX dataset URI