PXD048063-1

PXD048063 is an original dataset announced via ProteomeXchange.

Title	Proteomics of plasma exosomes reveals S100A8 as a novel biomarker for Alzheimer’s disease: a preliminary study
Description	Levels of blood exosomal Aβ42, total Tau (t-Tau) and phosphorylated Tau (p-Tau) had a high correlation with their concentrations in cerebrospinal fluid (CSF), demonstrating that exosomal biomarkers have equal contribution as those in CSF for the diagnosis of AD. We aimed to comprehensively characterize the proteome of plasma exosomes to identify differentially expressed proteins (DEPs) and pathways in AD. Tandem mass tag (TMT) labeled quantitative proteomics was applied to analyze plasma exosomal proteins in 9 AD patients and 9 healthy controls.
HostingRepository	iProX
AnnounceDate	2023-12-21
AnnouncementXML	Submission_2023-12-21_18:41:33.807.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guofeng Yang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-21 18:40:58	ID requested
⏵ 1	2023-12-21 18:41:34	announced

Dataset with its publication pending

submitter keyword: Alzheimer's disease, Exosomes, Proteomics, Biomarker, S100A8, siRNA

Guofeng Yang
contact affiliation	Department of Geriatrics, The Second Hospital of Hebei Medical University
contact email	gf_yang71@126.com
lab head
Guofeng Yang
contact affiliation	Department of Geriatrics, The Second Hospital of Hebei Medical University
contact email	gf_yang71@126.com
dataset submitter

iProX dataset URI