PXD047958 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Integrated Proteomic Profiling Identifies Amino Acids Selectively Cytotoxic to Pancreatic Cancer Cells |
Description | In this study, we carried out a proteomics analysis of cell and extracellular vesicles from nontumor and pancreatic adenocarcinoma (PDAC) tumor cells. We found out that PDAC cells preferentially excrete some proteins with preference for certain amino acids including isoleucine and histidine. Through in vitro and in vivo results, these amino acids demonstrate selective toxicity to PDAC cells and we subsequently identified XRN1 as a potential target of the amino acids. |
HostingRepository | PRIDE |
AnnounceDate | 2024-04-25 |
AnnouncementXML | Submission_2024-04-25_11:42:04.637.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alfred Akinlalu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-12-19 10:49:16 | ID requested | |
⏵ 1 | 2024-04-25 11:42:05 | announced | |
Publication List
Keyword List
submitter keyword: pancreatic adenocarcinoma, proteomics, amino acid treatment, cancer therapy |
Contact List
Dali Sun |
contact affiliation | University of Denver |
contact email | dali.sun@du.edu |
lab head | |
Alfred Akinlalu |
contact affiliation | University of Denver |
contact email | alfred.akinlalu@du.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD047958 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD047958
- Label: PRIDE project
- Name: Integrated Proteomic Profiling Identifies Amino Acids Selectively Cytotoxic to Pancreatic Cancer Cells