PXD047896 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A foundational atlas of autism protein interactions reveals molecular convergence |
| Description | Translating high-confidence (hc) autism spectrum disorder (ASD) genes into viable treatment targets remains elusive. We constructed a foundational protein-protein interaction (PPI) network in HEK293T cells involving 100 hcASD risk genes, revealing over 1,800 PPIs (87% novel). Interactors, expressed in the human brain and enriched for ASD but not schizophrenia genetic risk, converged on protein complexes involved in neurogenesis, tubulin biology, transcriptional regulation, and chromatin modification. A PPI map of 54 patient-derived missense variants identified differential physical interactions, and we leveraged AlphaFold-Multimer predictions to prioritize direct PPIs and specific variants for interrogation in Xenopus tropicalis and human forebrain organoids. A mutation in the transcription factor FOXP1 led to reconfiguration of DNA binding sites and altered development of deep cortical layer neurons in forebrain organoids. This work offers new insights into molecular mechanisms underlying ASD and describes a powerful platform to develop and test therapeutic strategies for many genetically-defined conditions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-03 |
| AnnouncementXML | Submission_2026-09-03_09:06:12.183.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Justin McKetney |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos; Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-12-18 03:05:16 | ID requested | |
| ⏵ 1 | 2026-09-03 09:06:12 | announced | |
| 2 | 2026-09-03 13:04:07 | announced | 2026-09-03: Updated project metadata. |
Publication List
Keyword List
Contact List
| Nevan Krogan |
|---|
| contact affiliation | Professor, Cellular and Molecular Pharmacology |
| contact email | nevan.krogan@ucsf.edu |
| lab head | |
| Justin McKetney |
|---|
| contact affiliation | University of California, San Francisco |
| contact email | justinmcketney@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD047896 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD047896
- Label: PRIDE project
- Name: A foundational atlas of autism protein interactions reveals molecular convergence
