PXD047851-1

PXD047851 is an original dataset announced via ProteomeXchange.

Title	Modeling the simultaneous dynamics of proteins in blood plasma and the cerebrospinal fluid in human in vivo
Description	The analysis of protein dynamics or turnover in patients has the potential to reveal altered protein recycling such as in Alzheimer disease, and to provide informative data regarding drug efficacy, or certain biological processes. The observed protein dynamics in a solid tissue or a fluid is the net result of protein synthesis and degradation, but also transport across biological compartments. We report a first model to simultaneously model protein dynamics observed in blood plasma and the cerebrospinal fluid (CSF) taking into account transport. We applied this model to 65 proteins of a single individual displaying similar or very different dynamics in plasma and CSF. The model structure indicates an active control at the blood-CSF barrier. This type of model has the potential to reveal altered transport or barriers resulting from disease in future studies.
HostingRepository	PanoramaPublic
AnnounceDate	2024-04-23
AnnouncementXML	Submission_2024-04-23_16:50:51.506.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	supported by repository but incomplete data and/or metadata
PrimarySubmitter	Jerome VIALARET
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Oxidation; Label:13C(6)
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-15 02:14:58	ID requested
⏵ 1	2024-04-23 16:50:52	announced

Dataset with its publication pending

submitter keyword: Proteomics, SILK, kinetic

Lehmann Sylvain
contact affiliation	Montpellier University Hospital
contact email	sylvain.lehmann@umontpellier.fr
lab head
Jerome VIALARET
contact affiliation	Montpellier University
contact email	jerome_vialaret@yahoo.fr
dataset submitter

Panorama Public dataset URI