PXD047820-3

PXD047820 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry imaging (MSI) combined with LC-MS/MS data from head and neck squamous cell carcinoma (HNSCC) xenograft samples to map peptide information
Description	Mass spectrometry imaging (MSI) was used to investigate different tumors regions from five head and neck squamous cell carcinoma (HNSCC) xenograft samples of tumor model CAL33. Specifically, the authors investigated if measurements could be attributed to tumor hypoxia. Hypoxic regions were defined using consecutive tissue slices which were stained with anti-pimonidazole polyclonal antibody. M/z values which were associated to hypoxic regions were converted to masses and mapped with masses from LC-MS/MS experiment. LC-MS/MS experiment was carried out on three different HNSCC xenografts samples from the same tumor model (CAL33). For details see: https://doi.org/10.21203/rs.3.rs-3755587/v1
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:31:49.562.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Verena Bitto
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480; rapifleX

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-14 01:52:21	ID requested
1	2024-02-28 02:37:33	announced
2	2024-05-29 03:01:43	announced	2024-05-29: Updated project metadata.
⏵ 3	2024-10-22 06:31:50	announced	2024-10-22: Updated project metadata.

Bitto V, H, ö, nscheid P, Besso MJ, Sperling C, Kurth I, Baumann M, Brors B, Enhancing mass spectrometry imaging accessibility using convolutional autoencoders for deriving hypoxia-associated peptides from tumors. NPJ Syst Biol Appl, 10(1):57(2024) [pubmed]

10.1038/s41540-024-00385-x;

submitter keyword: liquid chromatography, mass spectrometry imaging, HNSCC xenografts

Dr. Ina
contact affiliation	German Cancer Research Center (DKFZ), Division of Radiooncology / Radiobiology, Heidelberg Germany
contact email	ina.kurth@dkfz-heidelberg.de
lab head
Verena Bitto
contact affiliation	German Cancer Research Center (DKFZ)
contact email	verena.bitto@dkfz-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD047820

PRIDE project URI

• PRIDE
  1. PXD047820
     1. Label: PRIDE project
     2. Name: Mass spectrometry imaging (MSI) combined with LC-MS/MS data from head and neck squamous cell carcinoma (HNSCC) xenograft samples to map peptide information