PXD047815-2

PXD047815 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2 (APOL2)-mediated endoplasmic reticulum (ER) stress
Description	To investigate the functional role of APOL2 in liver fibrosis, we performed an unbiased immunoprecipitation-mass spectrometry (IP-MS) analysis for APOL2 in the TGF-β1-stimulated LX-2 cell lysates.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:54:50.131.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lu Gan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-13 22:38:34	ID requested
1	2024-08-13 03:08:43	announced
⏵ 2	2024-10-22 06:54:50	announced	2024-10-22: Updated project metadata.

Publication List

Gan L, Jiang Q, Huang D, Wu X, Zhu X, Wang L, Xie W, Huang J, Fan R, Jing Y, Tang G, Li XD, Guo J, Yin S, A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2. Nat Chem Biol, 21(1):80-90(2025) [pubmed]
10.1038/s41589-024-01704-3;

Gan L, Jiang Q, Huang D, Wu X, Zhu X, Wang L, Xie W, Huang J, Fan R, Jing Y, Tang G, Li XD, Guo J, Yin S, A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2. Nat Chem Biol, 21(1):80-90(2025) [pubmed]

10.1038/s41589-024-01704-3;

Keyword List

submitter keyword: APOL2, Anti-liver fibrosis,Natural small molecule, ER stress, HES1

submitter keyword: APOL2, Anti-liver fibrosis,Natural small molecule, ER stress, HES1

Contact List

Sheng Yin
contact affiliation	School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, Guangdong, P.R. China.
contact email	yinsh2@mail.sysu.edu.cn
lab head
Lu Gan
contact affiliation	School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, Guangdong, P.R. China.
contact email	ganlu27@mail2.sysu.edu.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD047815
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD047815

PRIDE project URI

Repository Record List

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