PXD047796 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tumor-intrinsic signatures of esophageal adenocarcinoma associate with cellular phenotypes and responses to therapy |
| Description | We have discovered the existence of 2 subtypes of esophageal adenocarcinoma (EAC): an intestinal-like (epithelial) subtype and a mesenchymal-like subtype. We aimed to discover distinct drug vulnerabilities in these subtypes, and found that the intestinal subtype is more sensitive to RTK inhibition. By profiling the phosphoproteome of our cell line panel (of which 4 are intestinal-like and 4 mesenchymal-like), we aim to elucidate distinct signalling pathways in our subtypes to explain different drug vulnerabilities. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-21 |
| AnnouncementXML | Submission_2026-05-21_10:06:51.383.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Thang Pham |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-12-13 10:45:37 | ID requested | |
| ⏵ 1 | 2026-05-21 10:06:51 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: chemoradiation,esophageal cancer, transcriptional regulation, heterogeneity, therapy resistance |
Contact List
| Connie Jimenez |
|---|
| contact affiliation | Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands |
| contact email | c.jimenez@amsterdamumc.nl |
| lab head | |
| Thang Pham |
|---|
| contact affiliation | Amsterdam UMC |
| contact email | t.pham@amsterdamumc.nl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD047796 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD047796
- Label: PRIDE project
- Name: Tumor-intrinsic signatures of esophageal adenocarcinoma associate with cellular phenotypes and responses to therapy
