PXD047673 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Global Lactylation Profiling Reveals Lactate-Driven Regulatory Mechanisms Promoting Tumor Progression in Oral Carcinoma |
Description | Cancer cells often rely on aerobic glycolysis for metabolism, and lactylation, a newly discovered post-translational modification, significantly impacts molecular processes. This study comprehensively analyzes lactylation's role in oral squamous cell carcinoma (OSCC), providing initial insights into its impact on progression. Six pairs of OSCC tissues underwent lactylation modification sequencing. 2,765 lactylation modification sites on 1,033 proteins were identified in OSCC, indicating its widespread presence. These modifications influenced metabolic activities, molecular synthesis, and transport. |
HostingRepository | PRIDE |
AnnounceDate | 2024-08-23 |
AnnouncementXML | Submission_2024-08-22_19:12:21.438.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Fengyang Jing |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-12-09 20:49:23 | ID requested | |
⏵ 1 | 2024-08-22 19:12:21 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, Proteome, Oral cancer |
Contact List
Fengyang Jing |
contact affiliation | Peking University School and Hospital of Stomatology |
contact email | jfyjfyjfy@bjmu.edu.cn |
lab head | |
Fengyang Jing |
contact affiliation | Peking University School and Hospital of Stomatology |
contact email | jfyjfyjfy@bjmu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD047673 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD047673
- Label: PRIDE project
- Name: Global Lactylation Profiling Reveals Lactate-Driven Regulatory Mechanisms Promoting Tumor Progression in Oral Carcinoma