PXD047535-2

PXD047535 is an original dataset announced via ProteomeXchange.

Title	Global Lactylation Profiling Reveals Lactate-Driven Regulatory Mechanisms Promoting Tumor Progression in Oral Squamous Cell Carcinoma
Description	Cancer cells often rely on aerobic glycolysis for metabolism, and lactylation, a newly discovered post-translational modification, significantly impacts molecular processes. This study comprehensively analyzes lactylation's role in oral squamous cell carcinoma (OSCC), providing initial insights into its impact on progression. Six pairs of OSCC tissues underwent lactylation modification sequencing. 2,765 lactylation modification sites on 1,033 proteins were identified in OSCC, indicating its widespread presence. These modifications influenced metabolic activities, molecular synthesis, and transport.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:56:01.735.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fengyang Jing
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	lactose glycated lysine
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-05 05:08:34	ID requested
1	2024-08-22 18:57:18	announced
⏵ 2	2024-10-22 06:56:02	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Human, Proteome, Oral cancer

Fengyang Jing
contact affiliation	Peking University School and Hospital of Stomatology
contact email	jfyjfyjfy@bjmu.edu.cn
lab head
Fengyang Jing
contact affiliation	Peking University School and Hospital of Stomatology
contact email	jfyjfyjfy@bjmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD047535

PRIDE project URI

• PRIDE
  1. PXD047535
     1. Label: PRIDE project
     2. Name: Global Lactylation Profiling Reveals Lactate-Driven Regulatory Mechanisms Promoting Tumor Progression in Oral Squamous Cell Carcinoma