PXD047519-1

PXD047519 is an original dataset announced via ProteomeXchange.

Title	Mesenteric Adipose-Derived Exosomal TINAGL1 Enhances Intestinal Fibrosis in Crohn's Disease via SMAD4
Description	Intestinal fibrosis, a severe complication in Crohn's Disease (CD), significantly impairs patient quality of life and lacks clear molecular understanding. Emerging evidence suggests a crucial role for mesenteric adipose tissue (MAT) in CD pathophysiology, particularly through its exosome secretion, which may modulate fibrogenic pathways. This study focuses on elucidating the role of MAT-derived exosomes in CD-related fibrosis, emphasizing their molecular composition and potential impact on disease progression.
HostingRepository	iProX
AnnounceDate	2023-12-04
AnnouncementXML	Submission_2025-10-09_18:12:44.832.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yidong Chen
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro; TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-04 18:32:40	ID requested
⏵ 1	2025-10-09 18:12:45	announced

Dataset with its publication pending

submitter keyword: Crohn's Disease, Intestinal Fibrosis, Exosomes, TINAGL1, TGF-β/SMAD4 Signaling

Liangru Zhu
contact affiliation	Huazhong University of Science and Technology
contact email	zhuliangru@hust.edu.cn
lab head
Yidong Chen
contact affiliation	Huazhong University of Science and Technology
contact email	chenyidongkyle@gmail.com
dataset submitter

iProX dataset URI