PXD047510-1

PXD047510 is an original dataset announced via ProteomeXchange.

Title	Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours
Description	In this study, we performed a comparative analysis of gut microbiota composition and gut microbiome-derived bacterial extracellular vesicles (bEVs) isolated from patients with solid tumours and healthy controls. After isolating bEVs from the faeces of solid tumour patients and healthy controls, we performed spectrometry analysis of their proteomes and next-generation sequencing (NGS) of the 16S gene. We also investigated the gut microbiomes of faeces from patientsand controls using 16S rRNA sequencing. Machine learning was used to classify the samples into patients and controls based on their bEVs and faecal microbiomes.
HostingRepository	PRIDE
AnnounceDate	2024-08-08
AnnouncementXML	Submission_2024-08-08_02:31:56.529.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Surbhi Mishra
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-04 08:16:04	ID requested
⏵ 1	2024-08-08 02:31:57	announced
2	2024-10-22 06:52:48	announced	2024-10-22: Updated project metadata.

10.1016/j.jare.2024.03.003;

Mishra S, Tejesvi MV, Hekkala J, Turunen J, Kandikanti N, Kaisanlahti A, Suokas M, Lepp, ä S, Vihinen P, Kuitunen H, Sunela K, Koivunen J, Jukkola A, Kalashnikov I, Auvinen P, K, ä, ä, ri, ä, inen OS, Pe, ñ, ate Medina T, Pe, ñ, ate Medina O, Saarnio J, Meril, ä, inen S, Rautio T, Aro R, H, ä, iv, ä, l, ä R, Suojanen J, Laine M, Erawijattari PP, Lahti L, Karihtala P, Ruuska TS, Reunanen J, Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours. J Adv Res, 68():375-386(2025) [pubmed]

submitter keyword: Bacterial extracellular vesicles

Gut microbiome

Solid tumour

Proteomics

Justus Reunanen
contact affiliation	Research Unit of Translational Medicine, University of Oulu, Biocenter Oulu, University of Oulu, Oulu, Finland
contact email	justus.reunanen@oulu.fi
lab head
Surbhi Mishra
contact affiliation	University of Oulu
contact email	surbhi.mishra@oulu.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD047510

PRIDE project URI

• PRIDE
  1. PXD047510
     1. Label: PRIDE project
     2. Name: Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours