PXD047492-1
PXD047492 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The effect of semaglutide on high-fat diet-induced liver cancer in obese mice |
| Description | This study aims to investigate the impact of semaglutide on the expression of liver cancer proteins in obese mice induced by a high-fat diet. Sixteen obese mice were randomly divided into two groups: the high-fat diet group and the semaglutide group, each consisting of eight mice. Additionally, eight normal male mice were included as the control group. Serum samples were collected, and a differential expression analysis of total proteins in adipose tissue was performed using quantitative tandem mass spectrometry (TMT) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Significant differential proteins were identified and subjected to bioinformatics analysis. The findings revealed that these differential proteins, namely ITGAV (integrin αV), LAMC1 (laminin γ1), FABP5 (fatty acid-binding protein 5), and LPL (lipoprotein lipase), regulate the occurrence and development of liver cancer by participating in the extracellular matrix (ECM) signaling pathway and the peroxisome proliferator-activated receptor (PPAR) signaling pathway. Notably, semaglutide can decelerate the progression of liver cancer by inducing the expression of ITGAV, LAMC1, FABP5, and LPL in the adipose tissue of obese mice. |
| HostingRepository | iProX |
| AnnounceDate | 2023-12-04 |
| AnnouncementXML | Submission_2023-12-03_23:55:20.104.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yanhui Liu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-12-03 23:54:57 | ID requested | |
| ⏵ 1 | 2023-12-03 23:55:20 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: LIHC, obesity, cancer, semaglutide, adipose tissue |
Contact List
| Shuchun Chen | |
|---|---|
| contact affiliation | Hebei General Hospital |
| contact email | chenshuchunwork88@163.com |
| lab head | |
| Yanhui Liu | |
| contact affiliation | Hebei North University |
| contact email | liuyanhui0504@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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