PXD047427-2
PXD047427 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | SARS-CoV-2-Infected hiPSC-Derived Cardiomyocytes Reveal Dynamic Changes in the COVID-19 Hearts |
Description | The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. Moreover, the disease’s extensive and sustained symptoms are now becoming a nonnegligible medical challenge. In this respect, data show that heart failure is one of the most common readmission diagnoses among COVID-19 patients. In this study, we used human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes to develop an in vitro severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection model and studied the dynamic changes occurring in cardiomyocytes after SARS-CoV-2 infection. Our findings highlight the importance of early detection and personalized treatment based on the disease stage. Finally, when our proteomics findings were combined with those of a virus-host interaction network analysis, we were able to identify several potential drug targets for the disease. |
HostingRepository | iProX |
AnnounceDate | 2023-12-01 |
AnnouncementXML | Submission_2024-02-25_22:05:14.762.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xiao Li |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-11-30 18:26:26 | ID requested | |
1 | 2023-11-30 20:17:51 | announced | |
⏵ 2 | 2024-02-25 22:05:15 | announced | 2024-02-26: Update information. |
Publication List
Li X, Hu H, Liu W, Zhang Q, Wang Y, Chen X, Zhu Y, Hu Z, Wang M, Ma J, Leng L, SARS-CoV-2-infected hiPSC-derived cardiomyocytes reveal dynamic changes in the COVID-19 hearts. Stem Cell Res Ther, 14(1):361(2023) [pubmed] |
Keyword List
submitter keyword: COVID-19, SARS-CoV-2, hiPSC-derived cardiomyocytes, heart, proteomics |
Contact List
Ling Leng | |
---|---|
contact affiliation | Peking Union Medical College Hospital |
contact email | lengling@pumch.cn |
lab head | |
Xiao Li | |
contact affiliation | National Center for Protein Sciences (Beijing) |
contact email | lixiaoBioinfo@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |