PXD047427-2

PXD047427 is an original dataset announced via ProteomeXchange.

Title	SARS-CoV-2-Infected hiPSC-Derived Cardiomyocytes Reveal Dynamic Changes in the COVID-19 Hearts
Description	The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. Moreover, the disease’s extensive and sustained symptoms are now becoming a nonnegligible medical challenge. In this respect, data show that heart failure is one of the most common readmission diagnoses among COVID-19 patients. In this study, we used human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes to develop an in vitro severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection model and studied the dynamic changes occurring in cardiomyocytes after SARS-CoV-2 infection. Our findings highlight the importance of early detection and personalized treatment based on the disease stage. Finally, when our proteomics findings were combined with those of a virus-host interaction network analysis, we were able to identify several potential drug targets for the disease.
HostingRepository	iProX
AnnounceDate	2023-12-01
AnnouncementXML	Submission_2024-02-25_22:05:14.762.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiao Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-30 18:26:26	ID requested
1	2023-11-30 20:17:51	announced
⏵ 2	2024-02-25 22:05:15	announced	2024-02-26: Update information.

Li X, Hu H, Liu W, Zhang Q, Wang Y, Chen X, Zhu Y, Hu Z, Wang M, Ma J, Leng L, SARS-CoV-2-infected hiPSC-derived cardiomyocytes reveal dynamic changes in the COVID-19 hearts. Stem Cell Res Ther, 14(1):361(2023) [pubmed]

submitter keyword: COVID-19, SARS-CoV-2, hiPSC-derived cardiomyocytes, heart, proteomics

Ling Leng
contact affiliation	Peking Union Medical College Hospital
contact email	lengling@pumch.cn
lab head
Xiao Li
contact affiliation	National Center for Protein Sciences (Beijing)
contact email	lixiaoBioinfo@163.com
dataset submitter

iProX dataset URI