PXD047381-1

PXD047381 is an original dataset announced via ProteomeXchange.

Title	The synaptic proteome and phosphoproteome is uniquely vulnerable to sleep loss during brain development while maturation confers resilience
Description	Sleep supports lifelong brain health and cognition. Sleep loss in early life can drive lasting changes in adult behavior, indicating sleep plays a distinct but poorly understood role supporting brain development. We systematically examined the molecular and behavioral adaptations and synaptic consequences of acute sleep deprivation (SD) in developing and adult mice. Developing mice lack robust adaptations to SD, exacerbating cognitive deficits. Synapse proteome and phosphoproteome analysis revealed profound vulnerability to SD in developing mice, including immediate impacts on synaptogenesis and key aspects of brain development. With maturation, a unified biochemical effect of sleep on synapses emerges, together with robust adaptations and resilience to SD. Our findings show sleep plays a distinct role in early life supporting synapse development, transitioning to homeostatic functions with maturation.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_14:37:37.403.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christine Mills
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-29 08:19:11	ID requested
⏵ 1	2024-10-08 14:37:38	announced
2	2024-10-22 07:00:56	announced	2024-10-22: Updated project metadata.

Gay SM, Chartampila E, Lord JS, Grizzard S, Maisashvili T, Ye M, Barker NK, Mordant AL, Mills CA, Herring LE, Diering GH, Developing forebrain synapses are uniquely vulnerable to sleep loss. bioRxiv, ():(2024) [pubmed]

10.1101/2023.11.06.565853;

submitter keyword: Synapses

Brain development

Sleep

Sleep deprivation

Graham Diering
contact affiliation	University of North Carolina at Chapel Hill; Cell Biology Department
contact email	graham_diering@med.unc.edu
lab head
Christine Mills
contact affiliation	University of North Carolina - Chapel Hill
contact email	allie.mills@unc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD047381

PRIDE project URI

• PRIDE
  1. PXD047381
     1. Label: PRIDE project
     2. Name: The synaptic proteome and phosphoproteome is uniquely vulnerable to sleep loss during brain development while maturation confers resilience