PXD047348-1

PXD047348 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Itaconate modulates immune responses via inhibition of peroxiredoxins
Description	Itaconate is a natural mild electrophile, able to modify free thiols in proteins upon activation. We submit two datasets investigating peptides modified by itaconate. Experiment001 contains data obtained from endogenous itaconate producing WT or itaconate incompetent Irg1-/- Bone marrow-derived macrophages stimulated with LPS for 24h. The second dataset from Experiment002 contains data obtained from WT Bone marrow-derived macrophages treated with media or 5 mM itaconic acid for 16h.
HostingRepository	MassIVE
AnnounceDate	2025-03-05
AnnouncementXML	Submission_2025-03-05_09:32:03.416.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jim Malone
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Oxidation; Carbamidomethyl; unknown modification
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-28 12:29:10	ID requested
⏵ 1	2025-03-05 09:32:03	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Itaconylation, thiol modification, peroxiredoxin inhibition

submitter keyword: Itaconylation, thiol modification, peroxiredoxin inhibition

Contact List

Maxim N Artyomov
contact affiliation	Washington University, School of Medicine, St Louis, MO
contact email	martyomov@wustl.edu
lab head
Jim Malone
contact affiliation	Washington University Sch
contact email	jmalone@wustl.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v06/MSV000093522/