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PXD047329-1

PXD047329 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in a human cartilage model
Description10-plex TMT dataset generated by immunoprecipitation of epitope-tagged COL2A1 constructs along with DSP-crosslinked interactors. This experiment allows for quantitative comparison of wild-type and Gly1170Ser COL2A1 interactomes in HT-1080 cells transiently transfected with COL2A1 under a constitutive promoter. Negative control samples are untransfected HT-1080 cells, used to identify high-confidence collagen-II interactors from non-specific binders.
HostingRepositoryMassIVE
AnnounceDate2023-11-28
AnnouncementXMLSubmission_2023-11-28_10:38:19.862.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterRichard Schiavoni
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListTMT6plex; Oxidation; Acetyl; Methyl
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-28 05:55:54ID requested
12023-11-28 10:38:20announced
Publication List
no publication
Keyword List
submitter keyword: COL2A1, Quantitative Proteomics, TMT Labeling,
Contact List
Matthew Shoulders
contact affiliationMIT
contact emailmshoulde@mit.edu
lab head
Richard Schiavoni
contact affiliationMIT
contact emailrpschiav@mit.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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