PXD047251-2

PXD047251 is an original dataset announced via ProteomeXchange.

Title	Generation of a deep mouse brain spectral library for transmembrane proteome profiling in mental disease models
Description	The establishment of a high-quality mouse brain transmembrane proteins spectral library enables in-depth profiling of the proteins across multiple brain regions. DIA data analysis, combining different search pipeline based on the spectral library, discovered a new GPCR regulator which was associated with depression verified via in vivo tests. This library represents a valuable resource that has the potential to discover the putative drug targets.
HostingRepository	iProX
AnnounceDate	2023-11-26
AnnouncementXML	Submission_2024-05-15_01:18:09.617.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shanshan Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-26 22:34:26	ID requested
1	2023-11-26 22:34:59	announced
⏵ 2	2024-05-15 01:18:10	announced	2024-05-15: Update information.

Li S, Luo H, Tang P, Tian C, Hu J, Lu H, Shui W, Generation of a Deep Mouse Brain Spectral Library for Transmembrane Proteome Profiling in Mental Disease Models. Mol Cell Proteomics, 23(6):100777(2024) [pubmed]

submitter keyword: mouse brain, spectral library, transmembrane proteome, data-independent acquisition, mental disorder

Wenqing Shui
contact affiliation	iHuman Institute, ShanghaiTech University
contact email	shuiwq@shanghaitech.edu.cn
lab head
Shanshan Li
contact affiliation	ShanghaiTech University
contact email	lishsh@shanghaitech.edu.cn
dataset submitter

iProX dataset URI