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PXD047235-1

PXD047235 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSerum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk
DescriptionIn-utero and dietary factors make important contributions towards health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights into studies of childhood diseases, which together with perinatal proteomes could reveal further perspectives. Accordingly, to determine differences between feeding groups and changes in infancy, serum proteomics analyses of mother-infant dyads with HLA-conferred susceptibility to type 1 diabetes (n = 22), weaned to either an extensively hydrolyzed or regular cow’s milk formula, were made. The LC-MS/MS analyses included samples from the beginning of third trimester, the time of delivery, 3 months postpartum, cord blood and samples from the infants at 3, 6, 9 and 12 months. Correlations between ranked protein intensities were detected within the dyads, together with perinatal and age-related changes. Comparison with intestinal permeability data revealed a number of significant correlations, which could merit further consideration in this context.
HostingRepositoryPanoramaPublic
AnnounceDate2024-05-27
AnnouncementXMLSubmission_2024-05-27_10:29:46.891.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportsupported by repository but incomplete data and/or metadata
PrimarySubmitterRobert Moulder
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListCarbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4)
InstrumentTSQ Vantage
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-25 10:28:08ID requested
12024-05-27 10:29:47announced
Publication List
Bhosale SD, Moulder R, Suomi T, et al (2024) Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk. iScience 110048. https://doi.org/https://doi.org/10.1016/j.isci.2024.110048
Keyword List
submitter keyword: Serum proteomics, age-trends, dietary intervention, type-1 diabetes, beta-cell autoimmunity
Contact List
Riitta Lahesmaa
contact affiliationTurku Bioscience
contact emailrilahes@utu.fi
lab head
Robert Moulder
contact affiliationTurku Bioscience
contact emailrobmou@utu.fi
dataset submitter
Full Dataset Link List
Panorama Public dataset URI