PXD047235-1

PXD047235 is an original dataset announced via ProteomeXchange.

Title	Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk
Description	In-utero and dietary factors make important contributions towards health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights into studies of childhood diseases, which together with perinatal proteomes could reveal further perspectives. Accordingly, to determine differences between feeding groups and changes in infancy, serum proteomics analyses of mother-infant dyads with HLA-conferred susceptibility to type 1 diabetes (n = 22), weaned to either an extensively hydrolyzed or regular cow’s milk formula, were made. The LC-MS/MS analyses included samples from the beginning of third trimester, the time of delivery, 3 months postpartum, cord blood and samples from the infants at 3, 6, 9 and 12 months. Correlations between ranked protein intensities were detected within the dyads, together with perinatal and age-related changes. Comparison with intestinal permeability data revealed a number of significant correlations, which could merit further consideration in this context.
HostingRepository	PanoramaPublic
AnnounceDate	2024-05-27
AnnouncementXML	Submission_2024-05-27_10:29:46.891.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	supported by repository but incomplete data and/or metadata
PrimarySubmitter	Robert Moulder
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	TSQ Vantage

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-25 10:28:08	ID requested
⏵ 1	2024-05-27 10:29:47	announced

Bhosale SD, Moulder R, Suomi T, et al (2024) Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk. iScience 110048. https://doi.org/https://doi.org/10.1016/j.isci.2024.110048

submitter keyword: Serum proteomics, age-trends, dietary intervention, type-1 diabetes, beta-cell autoimmunity

Riitta Lahesmaa
contact affiliation	Turku Bioscience
contact email	rilahes@utu.fi
lab head
Robert Moulder
contact affiliation	Turku Bioscience
contact email	robmou@utu.fi
dataset submitter

Panorama Public dataset URI