PXD047188 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Detection of candidate ovarian cancer protein biomarkers in sera using a multiplexed targeted mass spectrometry assay |
Description | Ovarian cancer is the most lethal gynecologic malignancy in women, and high-grade serous ovarian cancer (HGSOC) is the most common subtype. Currently, no clinical test has been approved by the FDA to screen the general population for ovarian cancer. This underscores the critical need for the development of a robust methodology combined with novel technology to detect diagnostic biomarkers for HGSOC in the sera of women. Targeted mass spectrometry (MS) can be used to identify and quantify specific peptides/proteins in complex biological samples with high accuracy, sensitivity, and reproducibility. In this study, we sought to develop and conduct analytical validation of a multiplexed Tier 2 targeted MS parallel reaction monitoring (PRM) assay for the relative quantification of 23 putative ovarian cancer protein biomarkers in sera. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-26 |
AnnouncementXML | Submission_2024-01-26_10:38:57.912.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Joohyun Ryu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-23 01:45:59 | ID requested | |
⏵ 1 | 2024-01-26 10:38:59 | announced | |
Publication List
Ryu J, Boylan KLM, Twigg CAI, Evans R, Skubitz APN, Thomas SN, Quantification of putative ovarian cancer serum protein biomarkers using a multiplexed targeted mass spectrometry assay. Clin Proteomics, 21(1):1(2024) [pubmed] |
10.1186/s12014-023-09447-4; |
Keyword List
submitter keyword: high-grade serous ovarian cancer (HGSOC), insulin-like growth factor-binding protein 2 (IBP2), serum,Parallel Reaction Monitoring (PRM), diagnostic biomarkers |
Contact List
Stefani Thomas |
contact affiliation | Department of Laboratory Medicine & Pathology, University of Minnesota |
contact email | stefanit@umn.edu |
lab head | |
Joohyun Ryu |
contact affiliation | University of Minnesota |
contact email | jryu@umn.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD047188 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD047188
- Label: PRIDE project
- Name: Detection of candidate ovarian cancer protein biomarkers in sera using a multiplexed targeted mass spectrometry assay