PXD047187-1

PXD047187 is an original dataset announced via ProteomeXchange.

Title	Proteoform-level drug target landscapes demonstrates a wider spectrum of ibrutinib targets
Description	In this study, we investigated the target landscape of the drug ibrutinib using thermal proteome profiling (TPP) and proteoform detection. Our findings demonstrated that ibrutinib interacts with multiple proteoforms, beyond its known targets. Specifically, we identified interactions related to immunomodulation, Golgi trafficking, endosomal trafficking, and glycosylation. These insights shed light on the clinical off-target effects and adverse events associated with ibrutinib. Moreover, our study emphasizes the significance of studyin drug interactions at the proteoform level and its potential implications for precision medicine.
HostingRepository	PRIDE
AnnounceDate	2024-11-24
AnnouncementXML	Submission_2024-11-24_15:48:55.399.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rozbeh Jafari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-23 01:32:19	ID requested
⏵ 1	2024-11-24 15:48:55	announced

10.1038/S41467-024-54654-8;

submitter keyword: acute lymphoblastic leukemia, ibrutinib, proteoforms,Thermal Proteoform Profiling

Rozbeh Jafari
contact affiliation	Karolinska Institutet, Department of Oncology-Pathology (OnkPat)
contact email	rozbeh.jafari@ki.se
lab head
Rozbeh Jafari
contact affiliation	Karolinska Institutet
contact email	rozbeh.jafari@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD047187

PRIDE project URI

• PRIDE
  1. PXD047187
     1. Label: PRIDE project
     2. Name: Proteoform-level drug target landscapes demonstrates a wider spectrum of ibrutinib targets