PXD047072-1

PXD047072 is an original dataset announced via ProteomeXchange.

Title	Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks
Description	The project is about studying the dynamics of PARP1 when bound to DNA and veliparib derivatives.
HostingRepository	PRIDE
AnnounceDate	2024-03-19
AnnouncementXML	Submission_2024-03-19_13:32:57.972.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ramya Billur
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-19 17:49:55	ID requested
⏵ 1	2024-03-19 13:32:58	announced

10.1042/bcj20230406;

Velagapudi UK, Rouleau-Turcotte É, Billur R, Shao X, Patil M, Black BE, Pascal JM, Talele TT, Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem J, 481(6):437-460(2024) [pubmed]

submitter keyword: PARP1, PARPi, HDX-MS, allostery

Dr. Ben E. Black
contact affiliation	Department of Biochemistry and Biophysics, University of Pennsylvania
contact email	blackbe@pennmedicine.upenn.edu
lab head
Ramya Billur
contact affiliation	St.Jude Childern's Research Hospital
contact email	ramya.billur@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD047072

PRIDE project URI

• PRIDE
  1. PXD047072
     1. Label: PRIDE project
     2. Name: Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks