PXD047026-2

PXD047026 is an original dataset announced via ProteomeXchange.

Title	Divergent venom effectors correlate with ecological niche in neuropteran predators
Description	Neuropteran larvae are fierce predators that use venom to feed on arthropods, but their venom system is poorly understood. The iconic antlions (Myrmeleontidae) are adapted to dry, sandy habitats, where they use pitfall traps and venom to catch and subdue large arthropod prey. The aphid lions, larvae of green lacewings (Chrysopidae) primarily hunt for smaller prey, such as aphids. Here, we investigate the tissue origin, composition and ecological role of venom in the European antlion Euroleon nostras and the green lacewing Chrysoperla carnea. We show that E. nostras venom has potent insecticidal activity, indicating its importance for efficient immobilization of large prey. C. carnea venom exerted no toxic effects, reflecting their specialization to small, non-defensive prey. Histological and proteotranscriptomic analysis revealed that antlion venom is produced in three distinct glands that secrete different proteins, indicating a functional compartmentalization of venom compounds. The venom system of E. nostras contains no bacteria, providing strong evidence that all venom compounds are of insect origin and not produced by bacterial symbionts as previously suggested. Our study provides a detailed analysis of the neuropteran venom system and new insights into venom biochemistry and function that may underpin the adaptation of antlions to their unique ecological niche.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:54:49.594.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jennifer Schwarz
SpeciesList	scientific name: Chrysoperla carnea; NCBI TaxID: 189513; scientific name: Euroleon nostras; NCBI TaxID: 516507;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-16 10:14:28	ID requested
1	2024-08-13 03:08:50	announced
⏵ 2	2024-10-22 06:54:49	announced	2024-10-22: Updated project metadata.

10.1038/S42003-024-06666-9;

submitter keyword: antlions,venom, aphid lions, Euroleon nostras, comparative venomics, Chrysoperla carnea

Dr. Heiko
contact affiliation	Department of Insect Symbiosis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany
contact email	hvogel@ice.mpg.de
lab head
Jennifer Schwarz
contact affiliation	European Molecular Biology Laboratory, Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
contact email	jennifer.schwarz@embl.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD047026

PRIDE project URI

• PRIDE
  1. PXD047026
     1. Label: PRIDE project
     2. Name: Divergent venom effectors correlate with ecological niche in neuropteran predators