PXD046869-1

PXD046869 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
Description	Lysosomes are active sites to integrate cellular metabolism and signal transduction. A collection of proteins enriched at lysosomes mediate these metabolic and signaling functions. Both lysosomal metabolism and lysosomal signaling have been linked with longevity regulation; however, how lysosomes adjust their protein composition to accommodate this regulation remains unclear. Using large-scale proteomic profiling, we systemically profiled lysosome-enriched proteomes in association with different longevity mechanisms. We further discovered the lysosomal recruitment of AMPK and nucleoporin proteins and their requirements for longevity in response to increased lysosomal lipolysis. Through comparative proteomic analyses of lysosomes from different tissues and labeled with different markers, we discovered lysosomal heterogeneity across tissues as well as the specific enrichment of the Ragulator complex on Cystinosin positive lysosomes. Together, this work uncovers lysosomal proteome heterogeneity at different levels and provides resources for understanding the contribution of lysosomal proteome dynamics in modulating signal transduction, organelle crosstalk and organism longevity.
HostingRepository	MassIVE
AnnounceDate	2024-02-01
AnnouncementXML	Submission_2024-02-01_08:45:23.948.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sung Yun Jung
SpeciesList	scientific name: Caenorhabditis elegans (NCBITaxon:6239);
ModificationList	Oxidation
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-11 14:49:23	ID requested
⏵ 1	2024-02-01 08:45:24	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: C. elegans lysosome

submitter keyword: C. elegans lysosome

Contact List

Meng Wang
contact affiliation	Baylor College of Medicine
contact email	wmeng@bcm.edu
lab head
Sung Yun Jung
contact affiliation	Baylor College of Medicine
contact email	syjung@bcm.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000093375/