PXD046841-1

PXD046841 is an original dataset announced via ProteomeXchange.

Title	Adrenergic Signaling and Proteomic Responses in Breast Cancer Spheroids: Implications for Tumor Microenvironment and Therapeutic Strategies
Description	Breast cancer, a global health challenge, exhibits molecular heterogeneity and complex interactions with the tumor microenvironment. We investigated adrenergic modulation in breast cancer spheroids, differentiating between basal-like (MDA-MB-231 and BT549) and luminal-like (T47D and MCF-7) subtypes. Noradrenalin reduced MDA-MB-231 spheroid size, reversed by propranolol, suggesting therapeutic potential. Luminal-like spheroids displayed subtler responses. Proteomic analysis revealed subtype-specific alterations, with TP53 as a consistent regulator affected by noradrenalin. Our study highlights subtype-dependent adrenergic signaling in breast cancer, providing insights for targeted therapies.
HostingRepository	PRIDE
AnnounceDate	2025-10-13
AnnouncementXML	Submission_2025-10-12_16:20:12.332.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ole Vidhammer Bjørnstad
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-10 03:02:48	ID requested
⏵ 1	2025-10-12 16:20:13	announced

Carrasco M, Bj, ø, rnstad OV, Vethe H, Akslen LA, Adrenergic signals influence proteomic responses in breast cancer cells. Front Neurosci, 19():1608017(2025) [pubmed]

10.3389/fnins.2025.1608017;

submitter keyword: breast cancer, proteomics, propranolol, noradrenalin,cancer, adrenergic signaling

Lars A. Akslen
contact affiliation	Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, Section for Pathology, University of Bergen, Bergen, N-5021, Norway Department of Pathology, Haukeland University Hospital, Bergen, N-5021, Norway
contact email	lars.akslen@uib.no
lab head
Ole Vidhammer Bjørnstad
contact affiliation	University of Bergen
contact email	ole.bjornstad@uib.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD046841

PRIDE project URI

• PRIDE
  1. PXD046841
     1. Label: PRIDE project
     2. Name: Adrenergic Signaling and Proteomic Responses in Breast Cancer Spheroids: Implications for Tumor Microenvironment and Therapeutic Strategies