PXD046799-1

PXD046799 is an original dataset announced via ProteomeXchange.

Title	Proteomic and Phosphoproteomic Analysis Reveals the Mechanisms of High Matrix Stiffness Induced Dormancy and Drug Resistance in Breast Cancer Repopulation Cells
Description	Cell dormancy is a major factor leading to drug resistance as well as the high rate of late recurrence and mortality in estrogen receptor-positive (ER+) breast cancer. Although some studies have highlighted the significant impact of the microenvironment on dormant cells, they have largely overlooked the mechanical forces stemming from the stiffness of the surrounding extracellular matrix. Previously, we demonstrated that soft matrix promotes tumor cell proliferation and migration, while stiff matrix induces tumor cell dormancy and drug resistance. In this study, we present a comprehensive analysis of the proteome and phosphoproteome in response to gradient changes in matrix stiffness, elucidating the mechanisms behind cell dormancy induced drug resistance. Overall, we found that membrane transport and anti-apoptotic processes may be mainly involved in mechanical force induced dormancy resistance of ER+ breast cancer cells.
HostingRepository	iProX
AnnounceDate	2024-09-11
AnnouncementXML	Submission_2024-09-10_20:11:02.813.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rong Han
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-08 18:00:51	ID requested
⏵ 1	2024-09-10 20:11:03	announced

Dataset with its publication pending

submitter keyword: Breast Cancer Repopulation Cells, High Matrix Stiffness

Juntao Yang
contact affiliation	Peking Union Medical College
contact email	superyjt79@163.com
lab head
Rong Han
contact affiliation	Peking Union Medical College
contact email	905556219@qq.com
dataset submitter

iProX dataset URI